Lean body mass and bone mineral density in physically exercising postmenopausal women
Tsutomu Douchi, Takashi Matsuo, Hirofumi Uto, Tomoki Kuwahata, Toshimichi Oki, Yukihiro Nagata
Department of Obstetrics and Gynecology, Faculty of Medicine, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan
Abstract
Objectives: To investigate whether the relative contribution of body composition (lean and fat mass component) to postmenopausal bone mineral density (BMD) differs between women participating in physical exercise and sedentary women. Methods: Subjects were 45 postmenopausal women participating in regular physical exercise and 89 sedentary controls aged 50–60 years. Baseline characteristics included age, height, weight, body mass index (BMI, Wt/Ht2), age at menopause, and years since menopause (YSM). Body fat mass, percentage of body fat, lean body mass, and lumbar spine BMD (L2-4) were measured by dual-energy X-ray absorptiometry. Results: Although age, height, weight, BMI, and YSM did not differ between the two groups, lean body mass and lumbar spine BMD were significantly higher (P<0.05 and <0.001, respectively), while body fat mass and percentage of body fat mass were significantly lower in exercising women than in sedentary controls (P<0.05 and <0.05, respectively). In exercising women, BMD was positively correlated with lean body mass (r=0.415, P<0.01) but not with body fat mass (r=0.155, NS). Conversely, in sedentary controls, BMD was correlated with body fat mass (r=0.251, P<0.05) and lean body mass (r=0.228, P<0.05). Conclusions: Lean body mass is a more significant determinant of postmenopausal BMD in physically exercising women than in sedentary women.